EB病毒抗体检测结合鼻内镜检查对鼻咽癌诊断的意义

The Significance of Combination of EB Virus Antibodies Detection and Nasendoscopy Examination in the Diagnosis of Nasopharyngeal Carcinoma

目的通过检测EB病毒VCA-IgA和EA-IgA抗体,并结合鼻内窥镜检查,对门诊就诊的广东地区患者进行鼻咽癌诊断。方法用间接免疫酶法检测门诊就诊的广东地区患者的EB病毒VCA-IgA和EA-IgA抗体,并用鼻内窥镜对抗体阳性的患者进行鼻咽部检查,对可疑的患者进行鼻咽部活检。结果门诊3 275例患者进行EB病毒VCA-IgA和EA-IgA抗体检测,VCA-IgA抗体阳性545例,EA-IgA抗体阳性39例,两项阳性39例,875例行鼻内窥镜检查,594例进行病理活组织检查,共确诊鼻咽癌患者79例。抗体阳性鼻咽癌检出率为14.13%。结论 EB病毒VCA-IgA和EA-IgA抗体检测并结合鼻内窥镜检查是鼻咽癌临床综合诊断的较好方法。

Objective To make nasopharyngeal carcinoma screening for the patients in the clinic service of Guangdong district via detecting EB virus VCA-IgA and EA-IgA antibodies, and nasendoscopy detection. Methods Do nose and throat biopsy for the suspicious patients with the method of Indirect enzyme immunity, detecting clinic service EB virus VCA-IgA and EA-IgA antibody,and testing nose and throat for the patients of antibody positive with nasendoscopy. Results There were 3 275 cases checked with EB virus VCA-IgA and EA-IgA antibody in the clinic service,with VCA-IgA positive 545 cases, EA-IgA antibody positive 39 cases ,and both positive 39 cases ,the nasendoscopy and pathology detection performed in 594 cases ,79 cases were diagnosed as nasopharyngeal carcinoma. Conclusion The detection of two antibodies （ EB virus VCA-IgA and EA-IgA）, together with nasendoscopy was the preferable method to nasopharyngeal carcinoma screening.