帕金森病患者血尿酸水平的检测及相关性分析

Assay of uric Acid in the Parkinson's Diseas Patients and Association Analyse

目的：探讨血尿酸与帕金森病（Parkinson＇s disease，PD）的关系。方法：选取2006年6月～2010年5月于我院门诊及住院部就诊并诊断为PD的患者46例为PD组，同时选取同期与PD组年龄、性别、民族相匹配的健康体检者46例为对照组，回顾性分析两组受检者空腹肘静脉血尿酸水平，并进行比较。结果：PD组血尿酸水平（273．1±59．3）μmol／L明显低于对照组（307．4±58．8）／μmol／L，（P=0．006）。PD患者Hoehm-Yahr分级Ⅰ～Ⅱ级（283．1±54．5）μmol／L、Ⅲ级（271．9±51．6）μmol／L、Ⅳ～Ⅴ级（260．6±76．7）μmol／L，3组之间血尿酸水平均无显著性差异（P=0．609）。PD患者的血尿酸水平与H—Y分级无明显相关性（r=0．194，P=0．197）。结论：PD患者血尿酸水平降低，低血尿酸水平可能是帕森病的危险因素之一，但不能作为PD患者病情严重程度的判断指标．

Objective ： To investigate the relationship between serum uric acid and Parkinson＇s disease. Methods： Totally 46 patients with Parkinson＇s disease receiving medical service in Yangtse River Ship General Hospital from June 2006 to May 2010 were chosen as experimental group, and 46 healthy persons whose age,sex and ethnic matched the PD patients were erolled as the controls. The fasting serum uric acid level of the two group subjects were retrospectively analyzed and compared. Results： PD group uric acid levels [（273.1± 59.3）μmol/L] were significantly lower than the control group（（307.4±58. 8）μmol/L] （P=0. 006）. PD patients were divided into three groups,grade Ⅰ - Ⅱ ,Ⅲ and Ⅳ-Ⅴ according to Hoehn-Yahr grade. Serum uric acid levels among the three groups[ Ⅰ - Ⅱ （283. 1±54. 5） μmol / L, Ⅲ （271.9±51.6）μmol / L and Ⅳ -Ⅴ （260. 6±76.7） μmol/L） were not significantly different （P=0. 609）. There was no siginificant correlation between uric acid and HY grade level in PD patients. Conclusions. The plasma uric acid in PD patients was lower healthy people. Low level of plasma uric acid is possibly one of the danger factors for PD, but it cafft reflect the severity of PD.