奥扎格雷联合桂哌齐特治疗脑梗死疗效观察

Effect of Ozagrel Combined with Cinepazide in Treatment of Cerebral Infarction

目的探讨奥扎格雷联合桂哌齐特治疗脑梗死的临床疗效。方法选取96例发病3d内的脑梗死患者,随机分为观察组和对照组各48例。两组患者均予马来酸桂哌齐特注射液160mg静滴,1次/d,观察组加用奥扎格雷钠注射液治疗,80mg静滴,1次/d。疗程均为14d。观察两组的临床疗效、治疗前后神经功能缺损评分及不良反应情况。结果观察组临床总有效率为91.7%,显效率81.3%,分别高于对照组的70.8%(P<0.01)、54.2%(P<0.01),两组患者治疗后神经功能缺损评分均明显低于治疗前(P<0.01),观察组神经功能缺损评分明显低于对照组(P<0.01),两组患者治疗过程中未见明显不良反应。结论奥扎格雷联合桂哌齐特治疗脑梗死具有疗效佳、安全性好,值得临床推广。

Objective To investigate the effect of ozagrel and cinepazide on treatment of cerebral infarction. Methods There were 96 patients with cerebral infarction within 3 days after onset. We divided them randomly into observation groups （48 cases）and control group（48 cases）. All patients were treated with cinepazide maleate,160 mg intravenous injection,once every day. Patients in the observation group were added ozagrel,80 mg intravenous injection,once every day. The course of treatment was 14 days. Clinical efficacy, neurological deficit score before and after treatment and adverse reactions were observed. Results The clinical total effective rate and the markedly effective rate of the patients in the observation group were 91.7% and 81.3%,respectively,which were higher than the 70.8% and 54.2% of the patients in the control group with a significant difference （P〈0.01） respectively. Neurological deficit score of the two groups after treatment were significantly lower than that before treatment （P〈0.01）. Neurological deficit score was significantly lower in observation group than that in control group （P〈0.01）,patients of both the two groups shower no significant adverse reactions during the treatment. Conclusion Ozagrel and einepazide on treatment of cerebral infarction show better effect and security, which if worthy of promotion.