肺癌患者血中D-二聚体和纤维蛋白原水平的变化及临床意义

Changes of Blood D-Dimer and FIB Levels in Lung Cancer Patients and Its Clinical Significance

目的探讨肺癌患者血中D-二聚体和纤维蛋白原水平的变化及临床意义。方法入选对象均为我院2007年1月～2009年12月的住院患者,包括30例肺癌、32例肺炎患者、28例健康体检者,分别检测三组血中D-二聚体和纤维蛋白原水平的变化情况。结果肺癌组的FIB、D-D水平明显高于肺炎组和健康对照组,差异有统计学意义(tFIB=4.53,4.63,P<0.01t;D-D=6.52,7.96,P<0.01)。肺炎组血中FIB、D-D平均水平均高于健康对照组,但差异无显著性(tFIB=0.358,P>0.05;tD-D=0.132,P>0.05)。结论检测肺癌患者血浆FIB及D-D水平,可用作判断其体内高凝和纤溶状态,预测其血栓发生的危险程度,估计病情发展状况的依据。

Objective To investigate content change and clinlic significance of D-dimer and FIB in the treatment of lung cancer. Methods The patients were selected in our hospital from January 2007 to December 2009,including 30 cases of lung cancer,32 cases of pneumonia patients and 28 healthy subjects. D-dimer and FIB in blood of three groups were detected. Results FIB and D-D in the lung cancer group was significantly higher than that in the pneumonia group and the healthy control group （tns=4.53,4.63,P〈 0.01;tD-D=6.52,7.96,P〈0.01）.FIB and D-D in the pnemnouia group were higher than that in healthy control group,bul the difference was not significant （tnR=0.358,P〉0.05;tD-D=0.132,P〉0.05）. Conclusion The detection of FIB and D-D in the patients with lung cancer can be used to judge the body coagulation and fibrinolysis. It can predict the risk of thrombosis level and estimated disease development .