2-氨基-5,6-二氢-苯并噻唑-7(4H)-酮的合成与表征

Synthesis and Characterization of 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one

以1,3-环己二酮(Ⅰ)为原料,在水相中与溴进行溴化反应制备2-溴-1,3-环己二酮(Ⅱ),产物未经提纯,直接将II与硫脲在乙醇介质中回流反应6 h合成了目标产物2-氨基-5,6-二氢-苯并噻唑-7(4H)-酮(Ⅲ),总收率为74%,合成产品通过乙醇重结晶进行了纯化,并通过核磁共振氢谱进行了结构确证。

2-Bromo-1,3-Cyclohexanedione（Ⅱ） was prepared with 1,3-Cyclohexanedione（Ⅰ） as the initial reactant that was brominated via bromine in aqueous phase.Further more,2-amino-5,6-dihydrobenzo[d]thiazol-7（4H）-one（Ⅲ） was prepared by the six-hour reflux reaction of Bromo-1,3-Cyclohexanedione（II） and thiourea in ethanol medium at 80 ℃.The yield was 74%.The synthetic products were purified through re-crystallization.Finally,the structure of these products was characterized by 1HNMR.