大肠癌组织中DOC-2和c-Fos蛋白的表达

Expressions of DOC-2 and c-Fos proteins in colorectal carcinoma tissue

目的:探讨DOC-2和c-Fos在大肠癌组织中的表达及其临床意义。方法:采用免疫组化SP法检测132例大肠癌组织及48例正常肠黏膜组织中DOC-2和c-Fos蛋白的表达情况。结果:大肠癌组织与正常肠黏膜组织中DOC-2的阳性表达率分别为31.1%(41/132)和81.2%(39/48),c-Fos的阳性表达率分别为56.1%(74/132)和12.5%(6/48),2组间差异均有统计学意义(χ2分别为35.911,27.051,P<0.001)。大肠癌组织中DOC-2的表达与患者年龄、性别、组织学类型、分化程度和临床分期无关(P>0.05),但与淋巴结及肝转移有关(P<0.05);c-Fos蛋白的表达与患者年龄、性别、组织学类型、临床分期、淋巴结及肝转移无关(P>0.05),但与分化程度有关(P<0.05)。大肠癌组织中DOC-2与c-Fos蛋白的表达呈负关联(rP=-0.368,P=0.001)。结论:DOC-2和c-Fos蛋白的异常表达可能在大肠癌的发生发展中起重要作用。

Aim：To investigate the expression and clinical significance of DOC-2 and c-Fos proteins in colorectal carcinoma tissue.Methods：The expressions of DOC-2 and c-Fos were detected by SP immunohistochemistry in samples including 132 cases of colorectal carcinoma tissue without radiotherapy or chemotherapy and 48 cases of para-carcinoma normal mucosa tissue.Results： The positive expression rate of DOC-2 was 31.1% in colorectal carcinoma,lower than that in normal mucosa tissue which was 81.2%.That of c-Fos was 56.1% in colorectal carcinoma,higher than that in normal mucosa tissue which was 12.5% （χ2 was 35.911,27.051 respectively,P0.001）.The expression level of DOC-2 had no relation with age,sex,histology type,differentiated degree or clinical stage,but with lymph node and liver metastasis（P0.05）.The expression of c-Fos was related to differentiated degree,but not to age,sex, histology type,clinical stage or lymph node and liver metastasis（P0.05）.There was negative association between the expressions of DOC-2 and c-Fos in colorectal carcinoma tissue（r=-0.368,P=0.001）.Conclusion： The imbalance of DOC-2 and c-Fos expression may play an important role in the occurrence and development of colorectal carcinoma.