基质金属蛋白酶-9（MMP-9）及其组织抑制剂TIMP-1与肺癌浸润转移及相应CT征象的关系

The effect of matrix metalloproteinase 9 （MMP-9） and its tissue inhibitor （TIMP-1） on invasion or metastasis of lung cancer and the association between them and signs of chest CT

目的研究基质金属蛋白酶-9（MMP-9）及其纽织抑制剂TIMP-1与肺癌浸润转移及CT征象的关系。方法用ELISA法检测血清中MMP-9和TIMP-1的含量．所有病例行胸部CT。结果MMP-9和TIMP-1在小细胞肺癌患者和非小细胞肺癌患者血清中的含量均显著高于正常对照组（P〈0．05）。MMP-9和TIMP-1在瘤体〉3cm、有纵隔淋巴结转移和存在分叶征者血清中的含量均显著高于瘤体〈3cm、无纵隔淋巴结转移和无分叶征者（P〈c）．05）。结论MMP-9、TIMP-1与肺癌浸润转移关系密切，检测血清中MMP-9和TIMP-1的含量有助于判断肿瘤的恶性度和转移的能力。

Objective： To study the effect of matrix metalloproteinase 9 and its tissue inhibitor （TIMP-I） on invasion or metastasis of lung cancer and study the association between them and signs with chest CT. Method： Fifty-six specimens were detected by enzyme-linked immunosorbent assay （ELISA）, and chest CT. Results： MMP-9 and TIMP-1 level in lung cancer patients was higher than that in health3＇ people （ P〈0.05 ） .And the MMP-9 and TIMP-1 level in lung cancer patients with mass diamitor〉3cm was higher than that with diamitor≤3cm, also the same relationship between patients with mass lobe and without mass lobe or with diaphram lymphoid node metastasis and without diaphram lymphoid node metastasis （P〈0.05） . Conclusion： There is a strong association between MMP-9, TIMP-1 and cancer dissemination. It＇s helpful for differentiating malignant or benign tumor and its metastasis capacity to determine the contenl of MMP-9 and TIMP-1 in blood serum.