妊娠期被动吸烟与出生缺陷关系的Meta分析

Relationship between Maternal Passive Smoking and Birth Defects during Pregnancy: a Meta-analysis

目的探讨孕期被动吸烟与出生缺陷的关系。方法运用计算机检索1980年至2010年4月国内外关于孕期被动吸烟与出生缺陷关系的研究文献,采用Cochrane协作网提供的RevMan5.0分析软件对入选的文献进行异质性检验,经Meta分析计算合并效应OR值及其95%CI。结果国内外25篇文献入选。森林图显示纳入文献是异质的（χ2=243.98,P〈0.000 01）,采用随机效应模型计算孕期被动吸烟与出生缺陷关联性的合并效应的OR值为1.70,95%CI：1.34~2.15。其中,国内和国外不同研究人群合并效应的OR值分别为3.62（95%CI：1.71~7.68）和1.28（95%CI：1.04~1.57）。结论孕期被动吸烟可能会增加出生缺陷发生风险。

Objective To evaluate the relationship between passive smoking during pregnancy and the birth defect.Methods The original articles published in the journals in English and Chinese respectively on the relationship between the passive smoking during pregnancy and birth defects of the subjects were scanned and evaluated.The homogeneity of the data was tested with software RevMan5.0 by Cochrane Collaboration.Meta-analysis was applied to calculate the combined odds ratio（OR） values and their 95% confidence intervals（CI）.Results Totally 25 original articles from the journals in domestic and abroad were selected for meta-analysis according to the selection criteria.Because all the studies selected were heterogeneous according to the ＂forest graph＂（χ2=243.98,P0.000 01）,the random effect model was used for calculation of the combined OR values.The combined OR value was 1.70（95%CI：1.34-2.15） for the total,3.62（95%CI：1.71-7.68） for the domestic and 1.28（95%CI：1.04-1.57） for the abroad,respectively.Conclusion Passive smoking of the subjects during pregnancy may increase the risk of birth defects.