摘要
全肠外营养(TPN)长期应用可以引起肠道并发症。其临床表现为腹痛、腹泻、恶心、呕吐、水电解质紊乱,甚至休克。发生机制可能与长期使用TPN使肠黏膜萎缩、肠屏障功能受损,导致病菌过度繁殖、移位有关。TPN肠道并发症的预防措施如下:尽可能缩短TPN使用时间;尽早与肠内营养联合使用;长期TPN支持的患者,可在TPN中加入丙氨酰谷氨酰胺及生长激素等营养因子。
Prolonged use of total parenteral nutrition（TPN） may induce intestinal complications.The clinical presentations of intestinal complications are abdominal pain,diarrhea,nausea,vomiting,water and electrolyte disturbance,and even a shock.The mechanisms of TPN-induced in testinal complications might be associated with atrophy intestinal mucosa and in testinal barrier damage,leading to bacterial overgrowth and translocation.The preventive measures for TPN-induced intestinal complications are as follows： th eduration of TPN use should be decreased if possible;TPN should be combined with enteral nutrition as early as possible.Alanyl-glutamine,growth hormone,and some other nutritional factors can be added to solutions for TPN in patients who were prolonged use of TPN.
出处
《药物不良反应杂志》
2010年第6期415-418,共4页
Adverse Drug Reactions Journal
关键词
全肠外营养
肠损害
细菌移位
并发症
total parenteral nutrition
intestinal damages
bacterial translocation
complications
