双环铂引起全血细胞减少

Dicycloplatin resulting in pancytopenia

1例71岁男性患者因右肺癌切除术后化疗,给予双环铂650 mg加入5%葡萄糖注射液1000 mL静脉滴注,4 h内输注完毕。次日,患者出现双下肢无力,恶心。3周后患者行第2次化疗,方案与第1次相同。次日,患者出现恶心、右侧鼻腔出血。实验室检查:WBC 3.04×109/L,N 0.50,L 0.37,Hb 83 g/L,RBC 2.76×1012/L,PLT 35×109/L。立即行鼻腔局部止血等对症治疗。3 d后鼻腔出血消失,血常规逐渐恢复正常,实验室检查:WBC 4.04×109/L,N 0.53,L 0.35,Hb 86 g/L,RBC4.16×1012/L,PLT 87×109/L。

A 71-year-old man received an IV infusion of dicycloplatin 650 mg in 5% glucose 1000 mL for chemotherapy after undergoing excision of right lung cancer.The infusion was completed within 4 hours.The next day,the patient developed weakness in lower limbs and nausea.Three weeks later,he received his second chemotherapy course and the regimen was the same as the first chemotherapy.The next day,he developed nausea and right nasal cavity bleeding.Laboratory tests revealed the following levels： WBC count 3. 04×109/L,N 0.50,L 0.37,Hb 83 g/L,RBC count 2.76×1012/L,PLT count 35×109/L.Local nasal cavity hemostasis and other symptomatic treatments were given immediately.Three days later,nasal cavity bleeding ceased and his routine blood tests normalized.Laboratory tests showed the following levels： WBC count 4.04×109/L,N 0.53,L 0.35,Hb 86 g/L,RBC count 4.16×1012/L,P LT count 87×109/L.