摘要
糖尿病肾病(diabetic nephropathy,DN)的发病机制尚不明确,近年来大量研究表明,Toll样受体4(Toll-like receptor4,TLR4)与DN密切相关。TLR4通过髓样分化因子88(myeloid differentiation factor88,MyD88)依赖性和非依赖性等途径激活下游信号分子,引发一系列的炎症反应,最终导致DN的发生与发展。
The precisely pathogenesis of diabetic nephropathy has not been fully clarified so far.Recent reports have indicated that Toll-like receptor 4（TLR4） may be involved in diabetic nephropathy.TLR4 signaling includes myeloid differentiation factor 88（MyD88） dependent and MyD88 independent pathway.The activation of TLR4 signaling pathway will lead to inflammatory reaction and in turn causing the development and progression of diabetic nephropathy.
出处
《国际病理科学与临床杂志》
CAS
2010年第6期523-526,共4页
Journal of International Pathology and Clinical Medicine
基金
湖南省教育厅科研项目(09C844)~~
关键词
TLR4
糖尿病肾病
炎症反应
Toll-like receptor 4
diabetic nephropathy
inflammatory reaction
