期刊文献+

实创巴马小型猪疑似糖尿病敏感个体筛选实验

Screening Test on Shichuang Bma Minipigs of Suspected Diabetes
下载PDF
导出
摘要 目的筛选疑似糖尿病敏感小型猪。方法测定79头(10~14月龄)实创巴马小型猪的体重指数、糖耐量,以及空腹血清GLU、TG、TC、HDL-C和LDL-C值,以空腹血糖值和糖耐量试验120 min血糖值为主要依据,同时参考其他相关检测指标,选择疑似糖尿病敏感小型猪。结果选择2对小型猪开始繁殖实验。 Objective To screen out the minipigs of suspected diabetes.Methods BMI,fasting serum GLU,TG,TC,HDL-C,LDL-C were detected and intravenous glucose tolerance test(IVGTT) were performed in 79 Shichuang Bama minipigs aged from 10 to 14 months.The minipgs were selected mainly based on fasting serum GLU level and 120 min GLU level in IVGTT,and the other reference indexes.Results Two pairs of the minipigs were selected for breeding test.
出处 《实验动物科学》 2010年第6期29-32,共4页 Laboratory Animal Science
基金 国家自然科学基金面上项目(批准号:30970418)
关键词 小型猪 糖耐量 糖尿病 Minipig Glucose tolerance test Diabetes
  • 相关文献

参考文献24

  • 1Zimmet P,Albert K G.Shaw J.Global and societal implications of the diabetes epidemic[J].Nature,2001,414:782-787.
  • 2Yang W,Lu J,Weng J,et al.Prevalence of diabetes among men and women in China[J].N Engl J Med.2010,362(12):1090-1101.
  • 3Kahn C R,Weir G C,King G L,et al.Joslin's Diabetes Mellitus[M].14th ed.Philadelphia:Lippincott Williama and Wilkins,2005.
  • 4Rees D A,Alcolado J C.Animal models of diabetes mellitus[J].Diabetic Medicine,2005,22(4):359-364.
  • 5Leiter E H.Mice with targeted gene disruptions or gene insertions for diabetes research:problems,pitfalls,and potential solutions[J].Diabetologia,2002,45:296-308.
  • 6Plum L,Wunderlich F T,Bandler S,et al.Transgenic and Knockout Mice in Diabetes Research:Novel Insights into Pathophysiology,Limitations,and Perspectives[J].Physiology,2005,20(3):152-161.
  • 7Bellinger D A,Merricks E P,Nichols T C,et al.Swine models of type 2 diabetes mellitus:insulin resistance,glucose tolerance,and cardiovascular complications[J].ILAR J,2006,47(3):243-258.
  • 8Liu Y,Wang Z,Yin W,et al.Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by highfat/hish-sucrose/hish-cholesterol diet[J].Exp Anim,2007,56(1):11-12.
  • 9Chen H,Liu Y Q,Huang LJ,et al.The susceptibility of threestrains of Chinese minipigs to diet-induced type 2 diabetes mellitus[J].Lab Animal 2009,38(11):355-363.
  • 10Bernardis L L,Patterson B D.Correlation between "Lee index" and carcass fat content in weanling and adult female rats with hypothalamic lesions[J].Journal of Endocrinology,1968,40:527-528.

二级参考文献36

共引文献73

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部