氟伐他汀对扩张型心肌病心力衰竭患者心功能和血清MMP-9水平的影响

Heart Function and serum MMP-9 Affection of Fluvastatin for Heart Failure due to Dilated Cardiomyopathy

目的观察氟伐他汀对扩张型心肌病心力衰竭患者心功能和血清MMP-9水平的影响，以及在心力衰竭患者中的用药安全性。方法选择48例DCM患者，随机分为干预组（25例）与对照组（23例）。干预组在对照组常规药物治疗基础上加用氟伐他汀。各组于治疗前后，分别检查各项心功能指标和血清MMP-9水平，并随访用药不良反应情况。结果治疗后干预组与对照组患者各项心功能指标均有明显改善，血清MMP-9水平明显下降，差异有统计学意义（P≤0．05）。两组间同期比较，干预组比对照组疗效更好，差异有统计学意义（P≤0．05）。两组患者随访未见用药不良反应。结论氟伐他汀对扩张型心肌病心力衰竭患者，有改善心功能，延缓心室重构的作用；氟伐他汀在DCM中应用是安全的。

Objective： To observe the affection of HF and serum MMP-9 by fluvastatin for HF due to DCM and drug safty.Methods： 48 cases of DCM patient were divided into interventional group （ 15 cases） and control group （39 cases） .The control group was treated with routine therapy.The interv- entional group was treated with fluvastatin based on routine therapy.The HF data , serum MMP-9 were detected before and after treatment, and follow-up drug adverse reactions.Results： The varied HF data had improved obviously and MMP-9 decreased with P〈0.05 within groups.The effect of interventional group was better than that in control group at same stage.And no drug adverse reactions.Conclusion： This drug might improve the heart function, delay ventricular remodeling and be safe to treat DCM.