摘要
以成骨性骨转移致低钙血症为首发表现的前列腺癌鲜见报道。本文报告1例76岁男性患者,实验室检查血钙轻度降低,血碱性磷酸酶、血前列腺特异性抗原明显升高,血甲状旁腺激素轻度升高。骨扫描示超级骨显像,X线摄片示腰椎、骨盆出现不规则骨密度增高区,前列腺穿刺及骨髓活检证实前列腺癌骨转移。给予抗雄激素治疗,唑来膦酸输注并补充钙剂及骨化三醇后症状缓解。
Hypocalcemia as the first manifestation of prostate cancer was rare reported. A 76-year-old male patient was admitted to our hospital with mild hypocalcemia. His laboratory examinations indicated extremely high level of serum alkline phosphatase （ALP） and prostate specific antigen （ PSA）, but only moderately increased parathyroid hormone （PTH） . Bone scintigraphy showed the pattern of ＂superscan＂. X-ray showed multiple osteoblastic bone metastases in lumbar spine, pelvis and proximal femur. Transrectal biopsy and bone marrow biopsy confirmed the diagnosis of pros- tate cancer with bone metastases. There was clinical improvement after androgen deprivation, zoledronate infusion and supplementation with calcium and calcitriol.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2010年第4期298-301,共4页
Chinese Journal Of Osteoporosis And Bone Mineral Research
关键词
低钙血症
成骨性骨转移
前列腺癌
hypocalcemia
osteoblastic metastases
prostate cancer
