摘要
目的观察周剂量多西他赛联合卡培他滨治疗晚期胃癌的近期疗效和不良反应。方法 37例晚期胃癌患者采用多西他赛35mg/m2,静脉滴注,第1,8天;卡培他滨1250mg/m2,bid,口服,1～14d,21d为1周期。3周期后评价疗效和不良反应。结果全组37例患者均可评价疗效,其中CR3例(8.1%),PR19例(51.3%),SD10例(27.0%),PD5例(13.5%),总有效率59.5%。中性粒细胞减少发生率54.0%。中位TTP为6.5个月(3.2～11.5个月),中位MST为10.3个月(5.8～14.7个月)。结论多西他赛联合卡培他滨治疗晚期胃癌有效率较高,血液学毒性低,近期疗效较好,用药方便、安全,明显提高了患者的生活质量。
Objective To evaluate the objective response rate and toxicity of weekly docetaxel combined with capecitabine in the treatment of advanced gastric cancer.Methods Thirty-seven patients with advanced gastric cancer were administrated with docetaxel 35 mg/m2 d1,d8,and capecitabine 1250 mg/m2 bid from day 1 to day 14.The cycles were repeated every 21 days.The treatment was finished after 3-4 cycles.Results Response and toxicity could be assessed in all the 37 patients.Three patients（8.1%）achieved complete response（CR）,19 cases（51.3%）partial response（PR）,10 cases（27.0%）stable disease（SD）,5 cases（13.5%）progression disease（PD）.The overall response rate was 59.5%.The major toxicity was myelosuppression,neutropenia was observed in 20 patients（54.0%）,gastro-intestinal toxicity was mild and renal or hepatic toxicity was not observed.Median time to progression and median overall survival time were 6.5 months（3.2-11.5months）and 10.3months（5.8-14.7months）respectively.Conclusion The weekly docetaxel combined with capecitabine regimen showed high response rate and manageable toxicity,and improved the quality of life in patients with advanced or metastatic gastric cancer.
出处
《中国肿瘤临床与康复》
2010年第6期544-546,550,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
