四川省新生儿乙型肝炎疫苗接种卫生经济学评价

The Impact and Health Economic Evaluation of Hepatitis B Vaccination for the Infant Population in Sichuan Province

目的研究四川省新生儿乙型肝炎(乙肝)疫苗(Hepatitis B Vaccine,HepB)接种的成本效果和效益,进行卫生经济学评价,促进HepB预防接种策略的巩固和发展。方法采用问卷调查的方式,对四川省和成都、泸州、资阳、巴中市,以及选定的县级疾病预防控制中心和预防接种单位,收集HepB接种成本资料;调查乙肝相关疾病患者患肝病期间的直接治疗费用,运用卫生经济学方法进行分析。结果四川省2007年进行的新生儿HepB接种,估计减少乙肝病毒表面抗原携带者48026例、慢性乙肝12006例、肝硬化1201例、肝癌120例。年直接效益为1.56亿元,总的成本效益比为3.85:1。结论四川省的HepB预防接种已经产生了可观的经济和社会效益。随着普遍接种及接种人数的不断增加,其所产生的社会效益将更加明显。

Objective To analyze health economical benefits of hepatitis B vaccine immunization strategy in order to consolidate and improve the immunization plan.Methods To calculate the cost of hepatitis B vaccination by cost analysis method.To study the direct treatment cost of hepatitis B,cirrhosis and liver cancer patients,a face to face questionnaire and health economic methods were adopted.The cost benefit analysis method was also used to calculate the cost benefit of HBV vaccine.Result Under the present immunization strategy,it is estimated that 48026 persons have been prevented from positive HBsAg,12006 persons from chronic HB,1201 persons from liver cirrhosis,120 persons from liver cancer by HepB vaccination in Sichuan province in 2007.The net benefit is 156 million yuan RMB,and the benefit-cost ratio is 3.85：1.Conclusion The current hepatitis B vaccine immunization strategy generates high economic benefit and it should be consolidated and improved.Along with hepatitis B vaccine immunization widespread,it will take more economic and social benefit.