麻疹流行后及麻疹减毒活疫苗强化免疫活动前后人群麻疹抗体水平研究

Study on Measles Antibody Level of the People after the Measles Epidemic and before and after Supplementary Immunization Actirities of Measles Vaccine

目的了解麻疹流行后人群麻疹抗体水平;评价麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)强化免疫活动(Supplementary Immmunization Activities,SIA)的效果。方法 2008年麻疹流行后,在新疆生产建设兵团辖区内,按照12个年龄组分层随机抽样,共采集有效血标本1415人份;跟踪监测其中8月龄～6岁的452名儿童,SIA1个月后再次采集有效血标本414份,应用酶联免疫吸附试验检测麻疹IgG抗体。结果①人群麻疹抗体阳性[≥200毫国际单位/毫升(mIU/ml)]率为85.5%,抗体平均浓度(Mean Consistency,MC)为819mIU/ml;其中<2岁和15～34岁人群抗体水平相对较低。20～40岁育龄期妇女麻疹抗体阳性率为84.7%,MC为694mIU/ml。南、北疆人群麻疹抗体阳性率和MC差异有统计学意义(χ2=45.802,t=9.848;P均<0.001)。②SIA后,目标儿童的麻疹抗体阳性率从88.9%提高到99.0%,MC从905mIU/ml提高至2410mIU/ml,各年龄组儿童抗体阳性率均>97%。结论新疆生产建设兵团目标人群在MVSIA后麻疹抗体水平显著提高。

Objective To know the antibody level of the people after the measles epidemic,and appraise the effect of the supplementary immunization activities（SIAs）of measles attenuated live vaccine.Methods 1415 samples were selected randomly which were divided into 12 age groups in Xinjiang Production and Construction Crops.One month after SIAs,414 the second serum samples were chosen from the 452 children among the age of 8 month to 6 years old.The measles virus specific IgG antibody was detected by ELISA.Results ①The total measles IgG antibody positive rate of the population was 85.5%,and the mean consistency（MC）was 811mIU/ml.The level of measles IgG antibody among the people under the 2 years old and 15～34 years old was very low.The measles IgG antibody positive rate of reproductive women was 84.7%,and MC was 694mIU/ml.There is significant difference of measles antibody positive rates between south and north of XinJiang Production and Construction Crops（χ2=45.802,P0.001;t=9.848,P0.001） ②The positive rate of targeted children was increased from 88.9% to 99.0%,MC was increased from 905 mIU/ml to 2410 mIU/ml.The positive rate in different ages groups were higher than 97%.Conclusion The measles antibody level was lncreased significantly after the SIAs.