我国育龄期妇女乙型肝炎病毒表面抗原及e抗原流行现状分析

Staus of the Hepatitis B Virus Surface Antigen and e Antigen Prevalence among Reproductive Women in China

目的了解我国(未包括香港、澳门特别行政区和台湾地区,下同)现阶段育龄期妇女乙型肝炎(乙肝)病毒表面抗原[Hepatitis B Virus(HBV)Surface Antigen,HBsAg]、抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)、乙肝病毒e抗原(HBV e Antigen,HBeAg)、抗乙肝病毒e抗原抗体(Antibody to HBeAg,Anti-HBe)的流行情况。方法用血清流行病学分析方法,在31个省(自治区、直辖市)的160个国家疾病监测点,多阶段随机抽取1～59岁常住人口,采集调查对象静脉血4ml,统一检测HBsAg、Anti-HBs。HBsAg阳性者再进一步检测HBeAg和Anti-HBe;对15～49岁育龄期妇女进行HBsAg及HBeAg流行状况分析。结果经加权调整后,我国育龄期妇女HBsAg流行率为6.61%,Anti-HBs流行率为47.33%。在HBsAg阳性育龄期妇女中,HBeAg流行率为23.51%,Anti-HBe流行率为75.54%。育龄期妇女HBsAg流行率在地区、城乡、民族和文化程度之间的差异无统计学意义,但20～24岁、30～34岁两组育龄期妇女,HBsAg流行率略高于全国育龄期妇女总HBsAg流行率。结论我国现阶段,育龄期妇女HBsAg流行率为6.61%,略低于全国一般水平。其中23.51%的HBsAg阳性妇女为HBsAg及HBeAg双阳性。

Objective To get the prevalence of Hepatitis B Virus（HBV）Surface Antigen（HBsAg）,antibody to HBsAg（anti-HBs）,HBV e Antigen（HBeAg）and antibody to HBeAg（anti-HBe）of the Child-bearing women in China（not include Hong Kong Special Administrative Region,Macao Special Administrative Region,and Taiwan Sheng）.Method National serosurvey was done,and participants were selected by multiple-stage sampling randomly from the 160 national disease surveillance sites.The data of Child-bearing women who were 15-49 years old were analyzed.Results The adjusted prevalence of HBsAg and anti-HBs was 6.61% and 47.33% respectively.Among the HBsAg positive women,the adjusted prevalence of HBeAg and anti-HBe was 23.51% and 75.54%.There was no significant difference in HBsAg prevalence between areas,city and rural,nationality and culture.Conclusions In China,the prevalence of HBsAg was 6.61% in child-bearing women,which is a little lower than that in the whole population.