甘肃省乙型肝炎病毒感染血清标志物的变化

Changes of Serum Markers Hepatitis B Virus Infection in Gansu Province

目的了解甘肃省乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)感染血清标志物的变化。方法对甘肃省1980、1992、2006年乙肝血清流行病学调查资料进行比较分析。结果甘肃省1～59岁人群乙肝病毒表面抗原(HBV Surface Antigen,HBsAg)阳性率由7.52%降至4.39%,1～9岁儿童HBsAg阳性率为1.66%,比1992年下降了77%;农村人群HBsAg阳性率均高于城市,城市人群HBsAg阳性率下降幅度大于农村;抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)阳性率由3.11%上升到49.48%,1992年随年龄增长而升高,2006年则随年龄增长而下降,1～9岁儿童Anti-HBs阳性率最高;HBV感染率和抗乙肝病毒核心抗原抗体(Antibody to HBVCore Antigen,Anti-HBc)阳性率均呈现随年龄的增长逐渐升高的趋势,但2006年的各年龄组人群HBV感染率和Anti-HBc阳性率均明显低于1992年。结论甘肃省1～59岁人群HBV感染率明显降低,乙肝疫苗免疫取得良好效果,尤其是针对儿童的免疫策略效果更为明显。

Objective To understand changes of serum markers of Hepatitis B infection in Gansu Province.Method Sero-epidemiological survey data of hepatitis B in 1980,1992 and 2006 in Gansu province were analyzed comparatively.Result HBsAg positive rate decreased from 7.52% to 4.39% in Gansu Province.HBsAg positive rate of children under 10 years old decreased to 1.66%,which decreased by more than77% compared with that of 1980 and 1992.HBsAg positive rate of the rural areas was higher than city,but decline of HBsAg positive rate in urban was larger than that in rural areas.AntiHBs rate significantly increased from 3.11% to 49.48%,and Anti-HBs rate of 1992 increased with age rising,while Anti-HBs rate of 2006 fell with age rising,and Anti-HBs rate of children under 10 years old was the highest.HBV infection and anti-HBc positive rate increased gradually with age rising,but all infection rate and positive rate of 2006 was significantly lower than that in 1992.Conclusion Hepatitis B infection rate decreased significantly in Gansu Province,which means that Hepatitis B vaccine has achieved good results,especially the effects of immunization strategies for children are more significant.