影响儿童横纹肌肉瘤预后的危险因素

Risk factors on prognosis of children with rhabdomyosarcoma

目的分析影响儿童横纹肌肉瘤（RMS）预后的危险因素。方法对56例RMS病历资料进行回顾性分析。结果单因素分析显示，肿瘤原发部位、大小、病理类型、临床分期、手术完全切除与否、不同治疗方案与RMS患儿生存时间存在相关性（P〈0．05）；多因素分析显示，临床分期是影响RMS患儿预后的独立危险因素（x＾2=8．762，P=0．003）。结论RMS的预后与肿瘤原发部位、大小、病理类型、临床分期、手术完全切除与否相关，临床分期是影响RMS患儿预后的独立危险因素，手术结合放化疗的综合治疗可提高RMS患儿生存率。

Objective To investigate risk factors which affect the prognosis of children with rhabdomyosarcoma （RMS）. Methods A total of 56 eases of RMS were evaluated in a retrospective analysis. Results In univariate analysis, tumor＇ s primary location and size, pathologic type, clinical stage,operation effect and therapeutic strategy were associated with prognosis of children with tlMS （P 〈0.05）. In multivariate analysis, clinical stage was an independent prognostic factor of RMS （X^2 = 8.762, P =0.003）. Conclusion Tumor＇ s primary location and size, pathologic type ,clinical stage, operation effect and therapeutic strategy are associated with the survival of children with RMS. Clinical stage is an independent prognostic factor of RMS. The therapeutic strategy combined with operation, adjuvant chemotherapy and radiotherapy can increase the survival rate.