B7/CD28家族共刺激分子在蒙古族儿童的川崎病发病机制中的作用

The Role of the B7/CD28 Costimulatory Molecules Family in the Pathogenesis of Kawasaki Disease on Mongolia Children

目的:阐明B7/CD28家族刺激分子在蒙古族儿童川崎病的发病机制中起到的重要作用。方法:通过荧光定量PCR对蒙古族儿童川崎病患者和用IVIG后ICOS和CTLA-4mRNA表达量变化进行研究。结果:川崎病组CTLA-4mRNA表达水平显著降低,比较有显著性差异(P<0.05),而ICOSmRNA表达水平显著增高,差异显著(P<0.05)。川崎病IVIG治疗组ICOSmRNA的表达显著降低(P<0.05),CTLA-4mRNA表达显著升高(P<0.05)。结论:B7/CD28家族成员中的活化及抑制作用,以及它们之间的相互关系,不仅可以探讨川崎病的发病机制,而且可能为它的免疫治疗提供新的思路。进而更好地为少数民族儿童的身体健康提供基础。

Objective：The B7/CD28 family of costimulatory molecules in the pathogenesis of Kawasaki disease Mongolian children played important roles.Methods： Mongolian children with Kawasaki disease,and after using IVIG,changes expression of the ICOS and CTLA-4mRNA level was detected by Quantitative PCR.Results： CTLA-4mRNA expression level of Kawasaki disease was lower（P〈0.05）,but the ICOS mRNA was higher（P〈0.05）.In the IVIG treatment group,the ICOS mRNA level was lower,and the CTLA4 mRNA was higher（P〈0.05）.Conclusion： As the main pathological changes in autoimmune vasculitis syndrome,kawasaki disease（KD） is an inflammation of small artery disease.B7/CD28 family members which can provide the second signal molecule T cell immune response abnormalities may be important in the pathogenesis.To better serve the health of minority children,this study provide a theoretical basis.