MRSA感染相关噬血细胞性淋巴组织细胞增多症两例附文献复习

MRSA Associated Hemophagocytic Lymphohistiocytosis Cases Report and Literature Review

目的 探讨耐甲氧西林金黄色葡萄球菌感染（MRSA）相：相关噬血细胞性淋巴组织细胞增多症（HLH）临床特征、治疗和预后.方法 通过两例典型病例深入分析MRSA感染相关HLH的临床表现、治疗方案和疾病转归以及结合该领域最新进展和文献进行讨论.结果 两例HLH患者均经病原学（细菌培养）检查确诊为MRSA感染,经过积极抗感染联合适当免疫抑制治疗,均好转出院.结论 MRSA感染为噬血细胞性淋巴组织细胞增多症罕见病因之一,由于病因明确,经过抗感染治疗联合免疫抑制治疗后预后优于其他原因导致的HLH.

Objective The aim of this study was to investigate clinical presentation,treatment profile and prognosis of methicillin-resistant staphylococcus aureus（MRSA） associated hemophagocytic lymphohistioeytosis（HLH）. Methods Through in-depth analyzing two typical cases, clinical features,treatment regimen and clinical outcome of MRSA related HLH were discussed by reviewing latest progresses and literatures in this field. Results MRSA infection was identified by bacterial culture, and both of them were cured by combination regimen of intensive anti-infection and proper immunosuppressive therapy. Conclusion It is concluded that MRSA infection is a rare pathogen of adult secondary HLH,and because of definite bacterial etiology and powerful antibiotics,most of MRSA associated HLH might have the better prognosis with the appropriate treatment compared to other secondary HLH.