溶血磷脂酸与急性脑梗死患者颈动脉斑块超声学特征相关性分析

Relationship between lysophosphatidic acid and the color Doppler ultrasonography data of carotid artery plaque of cerebral infarction patients

目的探讨溶血磷脂酸(LPA)与急性脑梗死患者颈动脉粥样硬化(CAS)斑块超声学特征的关系。方法选择发病3 d以内的急性脑梗死患者123例,分为无斑块组、硬斑块组和软斑块组。选择同期住院的非缺血性脑血管病患者50例为对照组,所有研究对象均进行颈动脉超声检查及LPA水平测定。结果脑梗死组LPA水平较对照组明显增高,CAS斑块总检出率及软斑块检出率高于对照组,软斑块组LPA水平高于硬斑块组和无斑块组,差异有显著性。结论脑梗死患者CAS斑块发生率高,斑块组成以不稳定的软斑块居多;LPA水平与软斑块关系密切。

【Objective】 To investigate the relationship between the concentration of lysophosphatidic acid（LPA） in blood and the color Doppler ultrasonography data of carotid artery sclerosis（CAS） plaque of cerebral infarction（CI） patients.【Methods】 A total of 123 patients who were diagnosed as cerebral infarction within 3 days were divided into 3 groups： non-plaque group,hard plaque group and soft plaque group.Another group of 50 patients who were hospitalized for non-ischemic cerebrovascular diseases were selected as controls.In all the subjects the level of lysophosphatidic acid was detected and carotid artery color Doppler ultrasonography was performed.【Results】 The level of LPA in the patients of the CI group was significantly higher than that in the control group（P〈 0.05）.The rates of overall plaques and soft plaques of the CI group were significantly higher than those of the control group.The level of LPA in the soft plaque group was significantly higher than those in the non-plaque group and hard plaque group.【Conclusion】 The rate of CAS plaques is high in CI patients.Most of the plaques are soft ones.The level of LPA is correlated with soft plaques.