异甘草酸镁联合门冬氨酸鸟氨酸治疗重型肝炎的临床观察

Treatment of severe hepatitis with magnesium isoglycyrrhizinate and ornithine aspartate

目的观察异甘草酸镁联合门冬氨酸鸟氨酸对重型肝炎的临床疗效。方法 75例重型肝炎患者,随机分为治疗组及对照组。对照组给予常规综合治疗;治疗组在综合治疗基础上,给予异甘草酸镁联合门冬氨酸鸟氨酸静滴,疗程为4周。治疗4周后比较两组患者的临床疗效及生化指标。结果治疗组的肝功能得到改善,凝血酶原活动度升高(P<0.01),治疗有效率增加(P<0.05)。结论在综合治疗基础上联用异甘草酸镁和门冬氨酸鸟氨酸能增强重型肝炎的疗效。

【Objective】 To observe effectiveness of magnesium isoglycyrrhizinate and ornithine aspartate for treating severe hepatitis.【Methods】 Totally 75 patients of severe hepatitis were randomly divided into treatment group and control group.Control group received regular comprehensive treatment,treatment group added magnesium isoglycyrrhizinate and ornithine aspartate to regular comprehensive treatment.Course of treatment was 4 weeks.After 4 weeks,the clinical curative effects and biochemical indexes were compared.【Results】 Liver function of patients in treatment group was improved,prothrombin activity raised（P 〈0.01）,treatment efficiency was increased（P 〈0.05）.【Conclusion】 Addition of magnesium isoglycyrrhizinate and ornithine aspartate can enhance effect of regular comprehensive treatment in treating severe hepatitis.