阿萨希毛孢子菌非系统播散性感染16例临床特点及诊治观察

ANALYSIS OF CLINICAL AND ANTIBIOTIC SUSCEPTIBILITY FOR 16 CASES OF NON-SYSTEM DISSEMINATED TRICHOSPORON ASAHII INFECTION

目的阿萨希毛孢子菌非系统播散性医院感染情况并药敏分析。方法对4年来河北医科大学第二医院住院患者标本中分离出的16例阿萨希毛孢子菌的病例资料进行回顾性调查,并采用生物梅里埃ATB Fungus-3进行药敏实验。以期对该菌引起感染的危险因素及抗真菌药物治疗方案进行探索及评估。结果 4年间共检出16株阿萨希毛孢子菌,检出率有逐年上升趋势。年龄以80岁以上为主,16例患者有13例采用呼吸机、导尿管等介入治疗。药敏实验及临床疗效证实两性霉素B显有良好的抗阿萨希毛孢子菌活性,其他抗真菌药物的疗效尚有争议。结论播散性感染外的阿萨希毛孢子菌感染有逐年上升趋势,对其感染的认识及抗真菌药物治疗应引起临床医生的高度重视。

Objective： To retrospectively analyse non- system disseminated trichosporon asahii infection and treatment strategy, Methods Retrospective analysis was used for 16 cases of non - system disseminated trichosporon asahii infection in rencent 4 years from the second hospital of Hebei medical university and antifugus test was used by bioMerieux ATB Fungus -3 to evaluate the bacteria infection risk factors and antifungal drugs treatment strategy. Results In recent 4 years,a totaI of 16 isolates were detected, detection rate was increased year by year. Mainly in patients over 80 years old, 13 eases were treated with respirator, catheters and other interventional !herapy. Antimicrobial susceptibilityi test and clinical effect shows that amphoteriein B has more antimicrohial activity to Trichosporon asahii. The efficacy of other antifungal agents is controversial. Conclusion The rate of non - system disseminated Trichosporon asahii infection was increased year by year. Clinicians should pay more attention to the infection and related treatment strategy