N末端B型利钠肽前体和高敏C反应蛋白对行直接经皮冠状动脉介入治疗的急性心肌梗死患者近期预后的预测价值

N-terminal pro-brain natriuretic peptide and high sensitivity C-reactive protein in assessing prognosis of patients with acute myocardial infarction after primary percutaneous coronary intervention

目的探讨N末端B型利钠肽前体(NT-proBNP)、高敏C反应蛋白(hs-CRP)对行直接经皮冠状动脉介入治疗(PCI)的急性心肌梗死(AMI)患者术后近期预后的预测价值。方法入选行直接PCI术的AMI患者61例,于术后2周测定血浆NT-proBNP和hs-CRP水平,PCI术后3d、3个月行超声心动图检查。观察住院期间及PCI术后3个月内心血管事件发生情况。结果左心室重塑组[左心室舒张末期容积指数增加率(ΔLVEDVI)≥20%]的NT-proBNP、hs-CRP水平均显著高于无左心室重塑组(ΔLVEDVI<20%,P值均<0.05),有心血管事件组的NT-proBNP、hs-CRP水平均显著高于无心血管事件组(P值均<0.05)。结论血浆NT-proBNP和hs-CRP水平对行直接PCI术后的AMI患者术后近期预后有一定的预测作用。

Objective To investigate the roles of plasma N-terminal pro-brain natriuretic（NT-proBNP）and high sensitivity C-reactive protein（hs-CRP）in assessing the prognosis of patients with acute myocardial infarction（AMI）after primary percutaneous coronary intervention（PCI）.Methods A total of 61 AMI patients receiving primary PCI were included in the present study.The plasma NT-proBNP and hs-CRP were measured within two weeks after primary PCI and the echocardiograms were taken at 3 days and 3 months after PCI.The vascular events were observed during hospitalization and within 3 months after PCI.Results The plasma NT-proBNP and hs-CRP levels were significantly higher in left ventricular remodeling group（left ventricular ejection fraction [ΔLVEDVI]≥20%）compared with those in left ventricular non-remodeling group（ΔLVEDVI20%,both P0.05）.And NT-proBNP and hs-CRP levels were significantly higher in the group with post-PCI cardiac events compared with those in the event free group（both P0.05）.Conclusion Plasma NT-proBNP and hs-CRP levels can be used to predict the prognosis of AMI patients after primary PCI.