腹腔镜直肠癌根治术对血清血管内皮生长因子C和可溶性白介素-2受体水平的影响及临床意义

Study on VEGF-C and sIL-2R in blood associated with laparoscopic radical resection of rectal cancer

目的探讨腹腔镜结直肠癌根治术对血清血管内皮生长因子C(VEGF-C)和可溶性白介素-2受体(sIL-2R)表达影响及其临床意义。方法收集2004年11月～2006年11月该院行根治性直肠癌手术患者150例,其中,腹腔镜组50例,开腹组100例,采用双抗体夹心酶联免疫方法(ELISA)检测两组术前和术后不同时期血清VEGF-C和sIL-2R水平,并进行两组间比较。结果腹腔镜组患者血清VEGF-C水平从术后第3天开始一直呈下降趋势,于术后第10天时已明显低于术前水平(P<0.05);而开腹组患者术后第3天血清VEGF-C水平出现升高,之后逐渐下降,术后1个月时明显低于术前水平(P<0.05),术后第3、7天与腹腔镜组同期比较差异有显著性(P<0.05)。两组患者术前血清sIL-2R从术后第3天开始两组患者血清sIL-2R水平水平均呈下降趋势,于术后第10天时均明显低于术前水平(P<0.05)。结论腹腔镜手术治疗直肠癌比传统开腹手术可能更具有优势,规范操作下不会增加肿瘤侵袭转移机会,安全性较好。

【Objective】To study the clinical significance of changes of serum SIL-2R and TNF-αlevels after laparoscopic radical resection of rectal cancer.【Methods】150 patients with rectal cancer were divided into laparoscopic operation group （50 cases）and open operation group （100 cases） randomly.Enzyme linked immunosorbent assay （ELISA） was used to detect the level of vascular endothelial growth factor C and solute IL-2R in serum before and afer operation.【Results】The serum VEGF-C level in the laparoscopic operation group decreased gradually after operation for 3 days and reached the lowest value on postoperative for 10 days （P 0.05）.The serum VEGF-C level was significantly high in the laparoscopic operation group than that in the laparoscopic operation group on postoperative for 3,7 days respectively （P 0.05）.The serum sIL-2R level in the laparoscopic operation group decreased gradually after operation for 3 days and reached the lowest value on postoperative for 10 days（P 0.05）.【Conclusions】The laparoscopic radical resection of rectal cancer could not raise the possibility of tumor metastasis compared with the open operation.