吡唑三杂环化合物的制备表征及生物活性的研究

Synthesis, Characterization and Antibacterial of Five-Membered Heterocycles

以1,3-二苯基-4-吡唑甲醛为原料,合成中间体吡唑腙和吡唑基氨基硫脲,进一步合成出一系列新颖的含有1,3,4-噁二唑,1,2,4-三氮唑和1,3,4-噻二唑的吡唑三杂环的化合物,通过抑菌圈法和营养肉汤法对所制备的化合物的抗菌活性进行了测试,测试结果表明:3-芳基-4-(1,3-二苯基-4-吡唑甲酰基)-1,2,4-三唑啉-5-硫酮对金黄色葡萄球菌具有良好的抗菌活性.

In this article,a new series of 1,3,4-oxadiazoles,1,2,4-triazoles,and 1,3,4-thiadiazoles were synthesized from the intermediates of hydrazone and thiosemicarbazide derivatives.All the compounds were evaluated for in vitro antibacterial activity using method of paper disc diffusion and nutrition broth dilution.The antibacterial data revealed that 3-aryl-4-（1,3-diphenyl-4-pyrazole-formyl）-1,2,4-triazoline-5-thione showed good activity against tested Gram-positive bacteria.