肾病综合征、肾小球肾炎患儿血清铜、锌、铁、镁与血清蛋白质的测定与分析

Determination of Copper、Zinc、Iron、Magnesium And Protein Concentrations In Serum of Children with Nephrotic Syndrome and Glomerulonephritis

采用原子吸收分光光度法,测定50 例肾病综合征患儿、28 例肾小球肾炎患儿血清铜、锌、铁、镁元素,并探讨这些元素与上述疾病的相互关系。结果显示,肾病综合征组和肾小球肾炎组血清锌均极显著低于正常组( P< 0-01) ,血清铁、镁与正常组比较无显著性差异,血清锌浓度与血清白蛋白、球蛋白含量呈显著正相关。肾病综合征组血清铜极显著低于正常组(P< 0-01) ,肾小球肾炎组血清铜与正常组比较无显著差异,血清铜浓度与血清白蛋白、球蛋白含量呈显著正相关。

The serum copper,zinc iron,magnesium and protein levels of 50 patients with nephrotic syndrome,28 patients with glomerulonephritis determined by atomic absorption spectrophotometry.The serum copper,zinc,iron,magnesium and protein in glomerulan diseases were analyzised.The results showed that the serum level of zinc in nephrotic syndrome group and glomerulonephritis group was significantly lower than normal group.The serum levels of iron,magnesium were of insignificant difference between glomerulan diseases group and normal group.There were significant positive correlations between serum zinc content and serum albumin content,and between serum zinc content and serum globulin content.The serum level of copper in nephrotic syndrome group was significantly lower than normal group.The serum level of copper were of insignificant difference between glomerulonephritis group and normal group.There were significant positive correlations between serum copper content and serum albumin content,and between serum copper content and serum globulin content.We suggest these changes are associated with the generation and state of disease.