小儿哮喘氯喹非松疗法的抗炎机理及临床疗效

Observation Of Anti-Inflammatory Mechanisms and Clinical Efficacy of CPP Therapy in Asthmatic Children

研究氯喹非松（ＣＰＰ）疗法的抗炎机理及疗效。方法：８２例哮喘患儿随机分为ＣＰＰ组和对照组，观察 ＣＰＰ组治疗前后 ＰＥＦ和 ＰＩＥＯ－ＰＥＦ的变化，并行两组疗效比较。 ６０只豚鼠被分为 ６组，致敏后给药并收集支气管肺泡灌洗液（ＢＡＬ），行ＷＢＣ和Ｅｏｓ计数。结果：（１）ＣＰＰ组经ＣＰＰ治疗后，哮喘的临床控制率为７３．０８％（３８／５２）、显效２１．１５％（１１／５２）、好转５．７８％（３／５２）、无效为０。对照组分别为３、１１、１４和２例，临床控制率两组差异有显著性（Ｐ＜０．０１）。ＣＰＰ组治疗后ＰＥＦ与ＰＤ－ＰＥＦ明显升高，ＢＨＲ下降（ｔ＝６２．０８，ｔ＝１７３．９４，均Ｐ＜０．０１）。（２）ＢＡＬ．液中ＷＢＣ和Ｅｏｓ计数均提示，氯喹可代替半量泼尼松。结论：该疗法对小儿哮喘疗效满意，哮喘动物模型证实其抗炎症效应明显。

To observe anti-inflammatory mechanisms and clinical efficacy of chloroquine, phenergan and prednisone (CPP)therapy. Method:82 cases of asthmatic children were randomly davided into CPP group and control group. Before and after treatment, the changes of PEF and PD20 PEF in the CPP group were observed. Clinical efficacy in the 2 groups were compared. 60 guinea pigs were divided into 6 groups. After being sensitized , various drugs and doses were used, following BALF collection. Results: In clinical asthma-control rate, there was significant difference between the CPP group(38/52)and. control group(3/30,x2 = 30 .28, P<0 .001 ). After treatment, PEF and PD20 PEF incresed greatly in the CPP group(t = 62.08, 173.94, P< 0. 01 ). WBC and the value in the BALF. Suggested that choroquine can be used to replace half the dosage of prednisone. Conclusion: The effect of CPP therapy is satisfactory in the treatment of asthmatic children. The experiment of asthmatic animal model has proved its strong anti-inflammatory effect.