颅脑降温仪在急性重症胰腺炎救治中的应用

Application of brain cool instrument in severe acute pancreatitis

目的观察颅脑降温仪在急性重症胰腺炎(SAP)中的治疗作用。方法 42例SAP患者随机分为处理组和对照组,每组21例。对照组仅给予常规治疗,处理组在常规治疗的基础上应用颅脑降温仪来控制体温,比较两组腹痛、腹胀和上腹压痛消失时间、恢复进食时间和血清TNF-α、IL-1β、淀粉酶变化。结果处理组患者腹痛、腹胀和上腹压痛消失时间、恢复进食时间均比对照组明显缩短(P<0.01或0.05),血清TNF-α、IL-1β和淀粉酶水平也比对照组显著下降(P<0.01)。结论颅脑降温仪可作为SAP的有效辅助疗法。

Objective To observe the role of brain cool instrument in severe acute pancreatitis （SAP）. Methods Forty-two SAP patients were randomly divided into control and treatment groups, and each received conventional therapy and conventional therapy plus brain cool instrument. Extinction time of abdominal pain, distension and epigastric tenderness, recovery of food taking, and serum levels of TNF-α, IL-1β and amylase were compared between both groups. Results Compared with control group, extinction time of abdominal pain, distension and epigastric tenderness, and recovery of food taking were shorter （P0.01 or 0.05）, while serum levels of TNF-α, IL-1β and amylase were downregulated （P0.01） in treatment group. Conclusion Brain cool instrument may act as a useful adjuvant treatment for SAP.