运动对预防大鼠高脂血症的作用及其机理研究

Molecular Mechanism of Aerobic Exercise on the Prevention of Hyperlipidemia for High Fat Diet Rats

大鼠在喂饲高脂高胆固醇饲料的同时，给予有氧运动（游泳）训练７周，观察有氧运动对高脂血症的预防作用并探讨其作用机理。结果发现：有氧运动可显著改善高脂膳食所引起的脂质代谢紊乱，有氧运动组大鼠的血ＴＣ，ＬＤＬ，ＨＤＬ，ＴＧ和Ａｐｏ Ｂ水平都明显低于高脂饲料组，血浆ＡｐｏＡＩ水平明显高于高脂饲料组。运动对高脂所引起的抗氧化能力下降有明显的恢复作用。同时运动可以减少ＬＤＬＲｍＲＮＡ在血管壁的表达，上调ＬＤＬＲ ｍＲＮＡ在肝脏的转录和蛋白表达，减少脂质沉积，促进脂质清除。

Rats fed with high fat and high cholesterol diet was forced to swin,Seven weeks later lipid level ,anti-oxidation capacity ,pathological changes and LDLR gene transcription and protein translation The results indicated tha aerobic exercise could significantly redress the lipid disorder and lower anti-oxidation capacity caused by high cholesterol diet. The alllevels of serum triglycerride, cholesterol,apo B and LDL of rats were significantly lower in triglyceride ,choleserol ,apo B and campared with those of high fat group While Apo AI and HDL level were significantly higher in exercise group The liver SOD level in exercise group was also significantly higher while MDA level reduced sharply The LDLR mRNA expression in aorta wall was up-regulated i high fat group ,however,exercise significantly reduced the LDLR nRNA expression Exercise also up-regulated the LDLR mRNA expression and protein translation in liver indicating the improvement of endogenous clearance and reduction of LDL deposit in the artery wall.