运动负荷大鼠心肌间质胶原形态重塑与心肌舒缩性能改变的研究

Research on the Morphologic Remodling of Intermycardial Collagen and Myocardial Systaltic Property Following Exercise Load in Rats

采用Ｓ－５７０型扫描电镜和ＲＭ－６２００多道生理记录仪观察分析了不同运动条件下心肌间质胶原形态重塑和心肌舒缩性能的变化。结果表明，一般运动负荷导致心肌细胞与间质胶原同步增长，心肌舒缩性能增强；长期运动超负荷导致心肌细胞与间质胶原不成比例增长，间质胶原过度增生，心肌舒缩性能受到较严重损伤。心室内压的±ｄ２Ｐ／ｄ２Ｐ／ｄｔ２ｍａｘ是反映心肌舒缩性能较敏感的指标。

Morphologic remodling of intermyocardial collagen and changes of myocardial systalitic property (MSP)in SD rat models wereobserved determined by scanning electron microsopy (S-570) and RM-6200 polygraph under the conditions of different exercise loads The results shower that proper led of exercise could lead to proponional increase in cardiac myscke cell (CKC) and in- termyocardial collagen stronger MSP overloaded exercise could cause the inproportonal increase of CMC and intermyocardial colla- gem ouerhyperplasia of mtermyocardial collagen and serious injury of MSP The left ventricualr +d2p/dt2 max is a rather snstive index in evaluatin MAP