多发性骨髓瘤不同治疗方案的临床疗效分析

The Effects Analysis of Different Trerapy Regimens Patients with Multiple Myeloma

目的探讨多发性骨髓瘤(MM)不同治疗方案的疗效。方法回顾性分析151例多发性骨髓瘤的临床资料,比较不同患者的临床疗效。结果 151例MM患者中,共有143例行化疗方案,总有效率为55.9%(80/143),其中完全缓解率21.0%(30/143)。联合化疗组的总有效率为61.3%(46/75),明显高于VD(硼替佐米+地塞米松)组的总有效率29.6%(8/27)(P<0.05)。MP(马法兰+强的松)、VD+MP组与VD组之间总有效率和PR率差异无统计学意义(P>0.05)。8例造血干细胞移植治疗的患者有7例存活,移植后9～67个月无疾病进展。结论联合化疗治疗MM具有良好的疗效,CR及PR比率较VD、MP、VD+MP组高,造血干细胞移植可提高生存期。

Objective To explore the effects of different regimens for the therapy of with multiple myeloma（MM）.Methods Response rates,MM Patients therapy with different protocols were retrospectively analyzed.Results In 151 patients,80 cases（55.9%） were total response and 30 cases（21.0%） were complete remission（CR）.The response rates were higher for the patients therapy with combination chemotherapy（CCT） than for those therapy with VD（29.6% versus 61.3%,P〈0.05）.Between MP,VD＋MP group and VD group,the CR rate and PR were no significant（P〉0.05）.The 8 patients received hematopoietic stem cell transplantation（HSCT）,7 remained alive in CR or PR with survival time of 9-67 months.Conclusion CCT yields higher response rates.HSCT could prolong survival time in patients.