血浆同型半胱氨酸水平与复发性脑梗死关系的相关性研究

Study on the correlation between the levels of hyperhomocystinemia and recurrent cerebral infarction

目的探讨复发性脑梗死患者的血浆同型半胱氨酸(homocystine,Hcy)水平及二者之间的相关性。方法选择116例脑梗死患者,其中复发性脑梗死56例,初发性脑梗死60例;采用免疫荧光法测定2组患者血浆同型半胱氨酸的水平。结果复发性脑梗死血浆同型半胱氨酸水平(26.0±5.9)μmol/L显著高于初发者(19.3±4.8)μmol/L;2组之间的年龄、性别、吸烟、饮酒、体质量指数、血脂水平及高血压病、糖尿病、心脏病的患病率无显著性差异(P>0·05)。结论血浆同型半胱氨酸的水平与复发性脑梗死之间有明显相关性,且是复发性脑梗死的危险因素。

Objective To explore the levels of hyperhomocystinemia in recurrent cerebral infarction and the correlation between them.Methods One hundred and sixteen patients with cerebral infarction were included,56 cases were recurrent cerebral infarction,while 60 cases were primary cerebral infarction;Hcy was measured by the fluorometric method.Results Plasma level of Hcy in recurrent cerebral infarction group（（26.0±5.9）μmol/L）was significantly higher than that in primary cerebral infarction group（（19.3±4.8）μmol/L）.There were no significant differences between the two groups in age,sex,history of smoking,drinking alcohol,body mass index,lipid,as well as the prevalence of hypertension,diabetes mellitus,and heart disease.Conclusion The level of plasma Hcy is closely associated with recurrent cerebral infarction,and it is a risk factor for recurrent cerebral infarction.