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P-gp与癫耐药相关性研究进展 被引量：6

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摘要 P-gp是由ABCB1基因编码的能量依赖性跨膜外向转运蛋白,在灶组织内的表达明显增加,影响AEDs通过血脑屏障,降低灶组织内AEDs浓度。给予P-gp抑制剂,不仅可以提高耐药细胞内AEDs浓度,也能增加灶组织内AEDs浓度,并扭转癫的耐药性。越来越多的研究从P-gp的结构、功能和过表达等方面阐述与癫耐药的相关性,现就这一方面的研究进展作一综述。
作者 顾浩 张庆
机构地区 宁夏医科大学 宁夏医科大学附属医院神经内科
出处 《中国实用神经疾病杂志》 2011年第4期89-92,共4页 Chinese Journal of Practical Nervous Diseases
关键词 癫 耐药性 P-糖蛋白
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献34

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二级参考文献14

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共引文献167

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引证文献6

二级引证文献21

中国实用神经疾病杂志
2011年 第4期

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