Tourette综合征患儿血浆生长抑素测定及行为评价

Plasma Somatostatin and Behavior Evaluation in Children with Tourette' s Syndrome

目的 :了解生长抑素 ( SS)在本病发病中的作用及其与行为之间的关系。方法 :采用放射免疫法对 3 0例患儿进行了血浆生长抑素放射免疫活性 ( SL I)的测定及事件相关电位的检测 ,并用 Achenbach儿童行为量表进行评价。结果 :发现患儿血浆 SL I明显增高 ,事件相关电位中 N1 0 0 、 P3 0 0 潜伏期显著延长。结论 :在本病发病机制中可能起一定作用 ,推测 SS是患儿异常行为的生化基础之一。

Objective:to explore the role of somatostatin in Tourette' s syndrome.Method:3 0 children with Tourette' s syndrome and 3 0 normal children were included.Using RIA to testthe plasma level of somatostatin.Achenbach Behavior Scale was used to determine pathological behavior of children.Event related potentials of them were also tested. Result:the plasma level of somatostatin in children with Tourette' s syndrome was significantly higher than that of normal control.The latencies of N1 0 0 and P3 0 0 of them were also prolonged significantly Conclusion:somatostatin may have some effectin the course of Tourette' s syndrome.