含联苯基的三氮唑和咪唑衍生物的合成

Synthesis of novel triazole and imidazole derivatives containing biphenyl

咪唑和三氮唑衍生物大多具有重要的生物活性,如抗惊厥,细菌抑制活性,抗真菌活性[1-3],其中一些衍生物是性能优良的医药或农药。作为医药唑类抗真菌药有较广的抗真菌谱,可用于局部使用,治疗皮肤真菌感染和酵母菌感染,部分药物可口服治疗全身真菌感染[4]。

Novel triazole and imidazole derivatives containing biphenyl were synthesized via F-C acylation,substitute reaction,reduction reaction starting from 2,4-difluorinbiphenyl.Title compounds 3,4,5 and 6 possess potential biological activity.The structures of novel compounds were confirmed by 1H NMR、IR、MS spectra and elemental analyses.