脂联素与妊娠期糖尿病的相关性研究

Study on the Correlation of Serum Adiponectin and Gestational Diabetes Mellitus in Pregnant Women

目的:探讨脂联素(adiponectin,ADP)与妊娠期糖尿病(gestational diabetes mellitus,GDM)的关系及其在GDM发病中的作用。方法:选取产科门诊孕28～32周的孕妇,正常糖代谢组(NGT)40人、糖耐量异常组(GIGT)32人、妊娠期糖尿病组(GDM)38人,利用ELISA方法测空腹ADP,并测空腹血糖、空腹胰岛素,根据霍马稳态模型(HOMAhomeostasis model)提出的公式,计算胰岛素抵抗指数,分析各指标间的相关性。结果:血清ADP浓度分别为NGT组(8.52±1.69)mg/L、GIGT组(5.88±2.97)mg/L、GDM组(4.37±2.43)mg/L,差异有显著性(P<0.01)。相关分析发现,血清ADP浓度与胰岛素抵抗指数、体重指数、空腹血糖和空腹胰岛素呈负相关(P<0.01)。结论:ADP是GDM的保护因子之一,是胰岛素的一个增敏剂。

Objective ：To investigate serum concentration of adiponectin（ADP） and correlation with insulin resistance in pregnant women with gestational diabetes mellitus（GDM） to provide the clinical evidence that ADP was one of the medicine of GDM.Methods：Among pregnant women at 28～32 weeks of pregnancy,three groups were divided.The first group was 40 cases of normal glucose tolerance（NGT）,the second group was 32 cases of impaired glucose tolerance（GIGT）,the third group was 38 cases of GDM.ELISA technique was employed to determine the serum ADP concentration,at the same time the fasting blood glucose,insulin concentration were detected.Insulin resistance index was calculated by HOMA,and the dependability of index was analyzed.Results：In the NGT,GIGT and GDM groups,the concentrations of serum ADP were（8.52±1.69）mg/L,（5.88±2.97）mg/L,（4.37±2.43） mg/L,respectively,and difference were significantly（P〈0.01）.The concentrations of serum ADP were correlated negatively with insulin resistance index,BMI,fasting blood glucose and insulin（P〈0.01）.Conclusion：ADP is one of the protection factors of GDM,and is a sensitizer of insulin.