冠心病与血三脂综合指数之间关系的研究

The Relationship between the Compositive Index of Triglycerin,Total Cholesterol,High-density Lipoprotein and Coronary Heart Disease

目的:研究血三脂综合指数(甘油三酯.总胆固醇∕高密度脂蛋白胆固醇指数,TG.TCH∕HDL-C指数)与冠状动脉粥样硬化性心脏病(CHD)之间的关系。方法:291例患者行选择性冠状动脉造影术,其中冠脉造影阳性者173例,为CHD组;阴性者118例,为对照(NT)组。TG.TCH/HDL-C以酶法测定,TG.TCH/HDL-C指数转化为Ln值表示。结果:CHD组三脂综合指数水平及异常率明显高于NT组(P<0.01);比值比(OR值)5.49。经多元逐步回归分析显示:与文中其它血脂指标相比,此指数与CHD之间显示了最有意义的回归关系(β值0.29,P值0.000 0,复相关系数0.47)。结论:高TG.TCH低HDL-C的联合作用较单一血脂异常对CHD形成具有更大危险性。TG.TCH/HDL-C指数可以做为一个评估CHD风险的较好指标。

Objective：To study the realitionship between compositive index of the three serum lipid varibles（triglycerin·total cholesterol/high-density lipoprotein,TG·TCH/HDL-C）and coronary heart disease（CHD）.Methods： TG、TCh and HDL-C were obtained in 291 cases undergoing coronary angiography（CHD was present in 173 patients and absent in 118 as normal control group）by Enzyme method.Results：The index（TG·TCH/HDL-C） of CHD group was significantly highter than that of normal control group（P〈0.01）and abnormailry rate of the index of CHD group was higher than that of control group（39.00% VS 10.37%,P〈0.01,OR=5.049）.Multivariate regression analysis revealed that compositive index was the most powerful variable associated with CHD compared with TG、TCH、HDL-C、cholesterol rates and TG/HDL-C respectively.Conclusion：The union action of highy TG、TCH and low HDLC concentration may be a much more dangerous factor in the formation of CHD than sigle blood lipld abnormality.Thus,TG·TCH/HDL-C may be a better index in predleting the danger of formation of CHD.