刺络拔罐治疗慢性持续期支气管哮喘的作用机制研究

Mechanism of Effect of Collateral-Pricking with Ventouse on Bronchial Asthma at Chronic Persistent Period

目的观察在常规治疗的基础上加刺络拔罐法对支气管哮喘慢性持续期的疗效,并探讨其治疗支气管哮喘的机制。方法根据患者就诊顺序编号,选择符合标准的患者48例,采用随机数字表法按1∶1的比例分成治疗组和对照组,治疗组24例,对照组24例。对照组给予常规治疗。治疗组在常规治疗的基础上,根据辨证选穴,于所选穴位行梅花针叩刺,再用闪火罐法于叩刺的穴位上闪罐,而后留罐,隔日一次,观察3个月。两组治疗前后进行肺功能检查,外周血血清总IgE及T淋巴细胞CD4+、CD8+检测。结果两组疗效比较差异有统计学意义(P<0.05)。组治疗后血清总IgE含量较治疗前差异均有统计学意义(P<0.01),两组治疗后比较差异有统计学意义(P<0.05)。两组患者治疗后FVC、FEV1、PEF较治疗前差异有统计学意义(P<0.05),但两组治疗后比较差异无统计学意义(P>0.05)。治疗组治疗后外周血CD4+水平、CD8+水平、CD4+/CD8+与治疗前比较差异均有统计学意义(P<0.05),且治疗后治疗组与对照组比较差异亦有统计学意义(P<0.05)。结论刺络拔罐治疗慢性持续期支气管哮喘,具有抗过敏、改善气道炎症、降低气道高反应性、提高机体免疫力的作用,有利于哮喘的长期稳定,操作简便、经济实用。

Objective To observe the clinical effect of conventional therapy combined with the collateral-pricking with ventouse on bronchial asthma at chronic persistent period,and to approach its mechanism. Methods Forty eight patients met the criterion were,according to the numerical orders of their visits and with the ratio of 1：1,divided into two groups by simple randomized method,i.e.,trial group and control group,with 24 in each.The patients in the control group were given conventional therapy,while those in the trial group were,based on the conventional therapy,given the collateral-pricking with ventouse：percussopunctator pricking on the acupoints which were selected by symptom differentiation,then quickly cupping and finally retained cupping on the acupoints,once every other day,for 3 months.The pulmonary function test,the content of total serum IgE,and the numbers of CD4＋ and CD8＋ T-lymphocytes in peripheral blood were examined for all the patients before and after treatment. Results There was a statistical significance in effect between the two group（P0.05）.In content of total serum IgE there was a statistical significance after the treatment as compared with before in both groups（P0.01）,and so there was after the treatment between the two groups（P0.05）.After the treatment in the levels of FVC,FEV1 and PEF a statistical significance was found in both groups（P0.05）,but no statistical significance was found between the two groups（P0.05）;CD4＋ in peripheral blood was decresed and CD8＋ was increased,and CD4＋/CD8＋ was decreased in both groups（P0.05）;meanwhile there was a statistical significance between the two groups（P0.05）. Conclusion The collateral-pricking with ventouse therapy for bronchial asthma at chronic persistent period can resist allergy,improve airway inflammation,reduce airway hyperresponsiveness,and raise immunity.It is beneficial for long-term stabilization of asthma,being simple in operation,economical and practical.