冠心病介入治疗致造影剂肾病98例临床分析

98 cases of contrast-induced nephropathy in patients who underwent coronary artery intervention

目的探讨冠心病介入治疗发生造影剂肾病(CIN)的影响因素及预防措施。方法回顾性分析2008年1月—2009年12月1700例行冠心病介入治疗的患者,分析CIN发生的危险因素以及预防性措施。结果 CIN总发生率为5.76%(98/1700)。CIN组合并高血压病、糖尿病、原有肾功能不全病史比例明显高于非CIN组(P<0.05),而LVEF以及24 h水化量明显低于非CIN组(P<0.05)。结论冠心病介入术前应积极评估患者的危险因素,同时应用水化疗法预防,可以最大限度地改善及纠正危险因素,尽量避免CIN的发生。

Objective To investigate the influence factors and prevention of contrast-induced nephropathy（CIN） in patients who underwent coronary artery intervention.Methods 1700 patients who underwent PCI or coronary angiograph from January 2008 to December 2009 were enrolled in this study.Clinical characteristics,risk factors and preventive actions were investigated.Results Among the 1700 patients,98 patients（5.76%） developed CIN.Compared with the non CIN patients, the incidence of pre-existing renal dysfunction,hypertension,diabetes mellitus in CIN patients increased significantly（P0.05）,the left ventricle ejective fraction and amount of hydration in 24 hours decreased significantly（P0.05）.Conclusion Positive evaluating the risk factors and using hydration can effectively improve and correct risk factors and reduce the incidence of CIN in patients who would undergo coronary interventional therapy.