醒脑静注射液对兔内毒素休克的血液流变学影响

Effect of Xingnaojing Injection on the Changes of Hemorheology in Rabbits with Endotoxic Shock

目的探讨醒脑静注射液对兔内毒素休克时血液流变学的改变及可能机制。方法日本大耳白兔18只,随机分为正常对照组、LPS组、LPS+XNJ组,每组各6只。用耳缘静脉推注LPS复制兔内毒素休克模型,再推注醒脑静注射液治疗。于0h、1h2、h、3h取血检测血液流变学指标。结果 LPS组与正常组比较,各时间点全血粘度(ηb)、血浆粘度(ηp)、血沉(ESR)、全血还原粘度(ηre)、红细胞聚集指数(EAI)、血沉方程K值(ESRK)均显著增高(P<0.05);LPS+XNJ组与LPS组比较,ηb、ηp、ESR、ηre均降低(P<0.05),且随时间延长其下降更加明显。结论醒脑静注射液能改善内毒素休克兔的血液流变性。

Objective To study the effect of Xingnaojing Injection on the changes of hemorheology in rabbits with endotoxic shock and the possible mechanism. Methods 18 rabbits were randomly divided into 3 groups： LPS（Lipopolysaccharide） group,LPS＋ Xingnaojing group and control group,6 rabbits in each;LPS was injected into the rabbits through helix vein to set up the model of endotoxic shock and then Xingnaojing Injection was given;at the time point of 0h,1h,2h and 3 h,the blood samples were taken for index detection of hemorheology. Result The ηb,ηp,ESR,ηre,EAI and ESRK in LPS group at each time point were much higher than those in control group（P0.05）;theηb,ηp,ESR andηre in LPS＋Xingnaojing Injection were lower than those in LPS group（P0.05） and the decrease became more significant with the time going. Conclusions Xingnaojing Injection may improve the blood rheology of the rabbits with endotoxic shock.