子宫动脉胎儿脐动脉血流变化对胎儿生长受限的临床意义

Clinical significance on fetal umbilical artery blood flow changes of uterine artery for the fetal growth restriction

目的:探讨子宫动脉胎儿脐动脉血流变化对胎儿生长受限的临床意义。方法:回顾性分析我院2007年1月～2010年5月收治入院的胎儿生长受限患者200例的临床资料。结果:观察组产妇子宫动脉脐动脉血流速度峰谷比(S/D)值为(2.70±1.26),对照组为(1.76±0.35);胎儿脐动脉S/D值分别为(2.39±0.38)和(2.85±0.61),两组比较,差异均有统计学意义(均P<0.01)。观察组经肝素治疗2个疗程后胎儿出生时平均每周双顶径、股骨长、头围、腹围增长及Apgar评分、体重情况与对照组比较,差异无统计学意义(P>0.05)。5例死亡病例产前胎儿脐血流检查S/D值升高,平均为(4.8±1.6)。说明彩色多普勒测量子宫动脉及胎儿脐动脉检查是评估胎儿疾病严重程度的最佳指标。结论:彩色多普勒测量子宫动脉及胎儿脐动脉检查可以作为胎儿生长受限的常规监测措施,了解治疗效果,确定分娩时机。肝素对于治疗胎儿生长受限效果显著,可作为临床首选药。

Objective：To observe the clinical significance on fetal umbilical artery blood flow changes of uterine artery for the fetal growth restriction.Methods：The clinical data of 200 patients of fetal growth restriction in our hospital from January 2007 to May 2010 were retrospectively analyzed.Results：In the observation group,the maternal uterine artery S/D was（2.70±1.26） and was（1.76±0.35） in the control group;fetal umbilical artery S/D was（2.39±0.38） and（2.85±0.61） respectively,the difference between the two groups was significant（P0.01）.The observation group treated with heparin after the baby was born two courses per week on average biparietal diameter,femur length,head circumference,abdominal circumference growth and Apgar score,body weight compared with the control group the situation was no significant difference（P0.05）.5 fatal cases of prenatal umbilical check S/D ratio increased with an average of（4.8±1.6）.That color Doppler measurement of uterine artery and fetal umbilical artery examination was to assess the fetus the best indicator of disease severity.Conclusion：Color Doppler measurement of uterine artery and fetal umbilical artery checks can be used as routine monitoring of fetal growth restriction measures,understand the treatment,to determine delivery time.Heparin for the treatment of significant effect of fetal growth restriction can be used as the preferred clinical medicine.