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蛋白酶活化受体-4在结肠癌组织中的表达及意义 被引量：3

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摘要 目的探讨蛋白酶活化受体-4(PAR-4)在结肠癌发生、发展中的作用。方法采用Real-time RNA法检测28份结肠癌组织及其相应癌旁组织中PAR-4表达,并采用2-ΔΔCt方法进行比较。结果 PAR-4在结肠癌组织中表达量明显增高,平均高出癌旁组织4.03倍;两者ΔCt比较,P<0.05;低分化结肠癌组织PAR-4表达量明显高于高分化及中分化组织(P<0.05);高分化与中分化组织PAR-4表达无显著差异。结论 PAR-4在结肠癌组织中尤其是低分化组织中呈高表达;PAR-4可促进结肠癌的发生及发展。
作者 陈琳 王峰 吴月平 陆仁飞 邵建国 王惠民
机构地区 南通市第三人民医院 南通大学附属医院
出处 《山东医药》 CAS 北大核心 2011年第7期43-44,共2页 Shandong Medical Journal
基金 江苏省社会发展项目2005029 南通大学附属医院科技项目Tdfy0962
关键词 蛋白酶活化受体-4 结肠癌 实时荧光定量聚合酶链反应
分类号 R735.3 [医药卫生—肿瘤]
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同被引文献62

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山东医药
2011年 第7期

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