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食管癌组织中p-4EBP1、p-S6K1表达及意义 被引量：1

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摘要 目的探讨p-4EBP1和p-S6K1在食管癌发生、发展中的作用。方法采用免疫组化SP法检测45份食管癌组织及20份正常食管组织中p-4EBP1及p-S6K1表达。结果食管癌组织中p-4EBP1和p-S6K1表达阳性率分别为71.1%和66.7%,正常食管组织中阳性率分别为25.0%和35.0%,P均<0.05;二者在食管癌组织中的表达呈正相关P<0.05(r=0.381)。结论 p-4EBP1和p-S6K1在食管癌发生、发展中起促进作用;二者可作为食管癌诊断、靶向治疗及预后判断的重要生物学标记物。
作者 王志永 阚云珍 赵利敏 马学莉 谢秋凤 关春荣
机构地区 郑州市第一人民医院
出处 《山东医药》 CAS 北大核心 2011年第7期63-64,共2页 Shandong Medical Journal
关键词 食管癌 真核细胞翻译起始因子4E结合蛋白1 核糖体S6蛋白激酶1
分类号 R735.1 [医药卫生—肿瘤]
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参考文献8

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共引文献3

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山东医药
2011年 第7期

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