摘要
探讨了褪黑素（ｍ ｅｌａｔｏｎｉｎ，ＭＴ）三个剂量［２５、７５、１２５ ｍ ｇ／（ｋｇ·ｄ）］、美沙酮两个剂量［２、４ｍ ｇ／（ｋｇ·ｄ）］及ＭＴ 长期保护用药等方法，对按剂量递增法形成的海洛因依赖性大鼠血液中的ＳＯＤ及ＮＯ 水平的影响。用药７ ｄ 组与自然戒断组比较（ｔ检验），ＭＴ２５、７５ ｍ ｇ／（ｋｇ·ｄ）两组的ＮＯ 水平明显高于对照组（Ｐ＜ ０．０５），ＭＴ１２５ ｍ ｇ／（ｋｇ·ｄ）组则有非常显著的差异（Ｐ＜ ０．００１），美沙酮组与对照组比较无统计学差异。以上各组ＳＯＤ 水平与对照组比较均无统计学意义。ＭＴ 长期用药组与单用海洛因组比较，其ＮＯ、ＳＯＤ水平均明显升高（Ｐ＜ ０．００１）。
NO and SOD levels in heroin dependent rats by gradually increasing doses of heroin were observed after using melatonin in three doses[25,75,125 mg/(kg.d)],methadone in two doses for 7 days and MT in multiple dose group. The results showed that NO level in MT group [25,75 mg/(kg.d),7 days] increased compared with that of control group ( P <0 05).While MT in 125 mg/(kg.d) improved obviously ( P <0 001),SOD was not different among every group in 7 days. NO and SOD levels in MT multiple dose group was quite different compared with that of heroin group ( P <0 001).
出处
《华西药学杂志》
CAS
CSCD
北大核心
1999年第5期329-331,共3页
West China Journal of Pharmaceutical Sciences
基金
全军医药科研基金
