凝血酶原活动度及白蛋白与肝组织病理损害的关系

Study on relationship between serum prothrombin activity albumin and the pathology of the liver.

目的 研究血清白蛋白 （ＡＬＢ） 及血浆凝血酶原活动度 （ＰＴＡ） 与肝组织病理损害的关系。方法 用酶速率法测定１３５ 例经病理证实的慢性肝炎、肝炎肝硬变及重型肝炎患者的ＡＬＢ， 用比浊法测定其ＰＴＡ。结果 在慢性肝炎轻度至中度， ＰＴＡ 较ＡＬＢ下降的百分率更高（Ｐ＜ ０．０１）； 随肝组织炎症程度及纤维化程度的加重， 各项指标均逐渐下降（Ｐ＜ ０．００１）， ＡＬＢ与ＰＴＡ 间相关系数为０．７２０（Ｐ＜ ０．００１）。结论 ＰＴＡ较ＡＬＢ更好地反映肝脏合成功能、储备功能，能更准确地反映肝脏的病理损害程度，

Objective To investigate the relationship between serum album(ALB)、plasma prothrombin activity(PTA)and the pathology of the liver.Methods 135 patients were diagnosed as chronic hepatitis,hepato cirrhosis and/or severe hepatitis by needle biopsy of liver,ALB were detected by enzyme rate method;PTA were detected by turbidimetry.Results The percentage of decrease of the of PTA level was higher than that of ALB in chronic mild,medium hepatitis( P <0 01);the level of ALB and PTA decreased gradully followed by the exacerbation of inflammatory reaction( P <0 001)and by the elevation of degree of fibrosis of the liver( P <0 001);their correlation coeficient was 0 720( P <0 001).Conclusion The level of PTA can better,more sensitively reflect the synthetic function and the damage of the pathology of the liver than that of ALB can do,they are all negatively relative to the pathology of the liver.