烟碱在大鼠海马诱导LTP的作用

Effect of nicotine on induction of long term potentiation in hippocampal CA 1 area of rat

目的 观察了烟碱在大鼠海马诱导长时程增强（ＬＴＰ） 的作用。方法 采用大鼠海马离体脑片灌流技术。结果 烟碱在大鼠海马ＣＡ１ 区可以诱发ＬＴＰ的作用；六烃季氨（Ｃ６） 可以阻断烟碱诱导ＬＴＰ；Ａｔｒｏｐｉｎｅ 对烟碱诱导ＬＴＰ作用无明显影响。无论在强直刺激前或后加入烟碱， 烟碱均可以易化强直刺激诱导ＬＴＰ的效应。结论 在大鼠海马ＣＡ１ 区烟碱可直接诱导ＬＴＰ，该作用由烟碱受体介导。烟碱可易化强直刺激诱导ＬＴＰ作用，提示两者诱导海马ＬＴＰ

AIM The effect of nicotine on long term potentiation (LTP) in hippocampal CA 1 area was observed. METHOD Electrical stimulation was delivered to the Schaffer commissural fiber system and extracellular recording was performed at the pyramidal cell body layer in CA 1 area of hippocampal slices. Population spikes were recorded to study the induction of LTP. RESULTS The results showed nicotine could induce long term potentiation in hippocampal CA 1 area of rat. C 6 could block nicotinic LTP,but atropine couldnt do it. The amplitude of tetanic LTP could be increased by nicotine. CONCLUSION Nicotine could directly induce by nicotinic receptor the induction of tetanic LTP in hippocampal CA 1 area of rat. Nicotine could facilitate tetanic LTP. The results suggest that both of induction mechenism were different.