艾叶油的呼吸系统药理研究-Ⅱ,抗过敏作用

Studies on the respiratory pharmacology of essential oil extracted from Artemisia argyi-Ⅱ,effects of antianaphylactic effects

目的：本文研究艾叶油的抗过敏作用。方法：采用致敏豚鼠气管ＳｃｈｕｌｔｚＤａｌｅ 反应，组胺或氨甲酰胆碱引起的豚鼠气管收缩，大鼠被动皮肤过敏，５羟色胺引起的大鼠皮肤毛细血管通透性增强，豚鼠肺组织释放过敏性慢反应物质（ＳＲＳＡ） ，ＳＲＳＡ 收缩豚鼠回肠等试验。结果：艾叶油抑制致敏豚鼠气管ＳｃｈｕｌｔｚＤａｌｅ 反应（ＩＣ５０ ：９８ ．６ｍｇ／Ｌ） ；１００ｍｇ／Ｌ 明显降低组胺或氨甲酰胆碱引起的豚鼠气管收缩ｐＤ２ 值；明显抑制大鼠被动皮肤过敏（ＩＤ５０ ：０ ．２２ｇ／ｋｇ） 和５羟色胺引起的大鼠皮肤毛细血管通透性增强反应（ＩＤ５０ ：０ ．５２ｇ／ｋｇ） ；抑制豚鼠肺组织释放ＳＲＳＡ（ＩＣ５０ ：４９ ．７ｍｇ／Ｌ） ；拮抗ＳＲＳＡ 对豚鼠回肠的收缩（ＩＣ５０ ：３４ ．９ｍｇ／Ｌ） 。结论：艾叶油具有抗过敏作用，对呼吸道过敏反应有保护作用。

OBJECTIVE:To evaluate the antianaphylactic effects of essential oil extracted from Artemisia argyi.METHODS:The following experiments were carrind out:tracheal Schultz Dale reaction in the sensitized guinea pigs,histamine or carbarylcholine induced tracheal contraction in guinea pig,the passive cutaneous anaphylaxis and 5 HT induced cutaneous capillary permeability in rats,the release of SRS A in the lung of guinea pigs,and SRS A induced ileum contraction in guinea pig.RESULTS:The oil of Artemisia argyi inhibited the tracheal Schultz Dale reaction in the sensitized guinea pigs(IC 50 :98.6mg/L).At the concentration of 100mg/L,the oil inhibited histamine or carbarylcholine induced tracheal contraction in guinea pig,shifting the dose effect curve to the right.Moreover,the oil significantly inhibited the passive cutaneous anaphylaxis and 5 HT induced cutaneous capillary permeability in rats(ID 50 :0.22 and 0.52g/kg),inhibited the release of SRS A in the lung of guinea pigs(IC 50 :49.7mg/L),and inhibited the SRS A induced ileum contraction in guinea pig(IC 50 :34.9mg/L)as well.CONCLUSION:Oil of Artemisia argyi has the effects of antianaphylaxis.It is beneficial for the treatment of asthma and chronic bronchitis.